Nitro and amino derivatives of lucanthone as antitumor agents
- 1 March 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (3), 328-331
- https://doi.org/10.1021/jm00345a020
Abstract
A group of nitro and amino derivatives of lucanthone was prepared and tested for antitumor activity. Reaction of 1-chloro-4-methyl-7-nitrothioxanthenone and N,N-diethylethylenediamine gave the 7-amino analog (11) directly, accompanied by 7-amino-1-chloro-4-methylthioxanthenone. The antitumor activity of 11 was inferior to that of lucanthone and 7-hydroxylucanthone. The most active compound in the series was the nitro compound 1. In the [mouse] P-388 lymphocytic leukemia screen it showed substantial activity.This publication has 1 reference indexed in Scilit:
- Nitro and amino derivatives of lucanthone as antitumor agentsJournal of Medicinal Chemistry, 1982