Micro vascular permeability to albumin and glomerular filtration rate in diabetic and normal children
- 1 May 1979
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 16 (5), 307-311
- https://doi.org/10.1007/bf01223619
Abstract
In order to examine the permeability of microvessels in diabetic children, the glomerular filtration rate, urinary excretion rates of albumin and β2-microglobulin, intravascular mass of albumin, and transcapillary escape rate of albumin were studied in 26 diabetic children without clinical signs of microangiopathy (age: 7–14 years; duration of disease: 3–14 years). Similar measurements were made in 28 healthy school children (age: 8–14 years). Mean glomerular filtration rate in the diabetic children was higher than in the normal children (138 versus 109 ml/min per 1.73 m2, p2-microglobulin did not differ in diabetics. Mean intravascular albumin mass in the diabetic girls (1.64 g/kg body weight) was lower (p<0.01) than in the diabetic boys (1.89 g/kg body weight) and also lower (p<0.02) than in the normal girls (1.94 g/kg body weight). Mean transcapillary escape rate of albumin in the twenty diabetics with duration of diabetes less than 10 years (7.14%/h) was lower (p<0.01) than that in normal children (8.90%/h); the escape rate showed a positive correlation with duration of diabetes (r=0.47; p<0.02). Thus glomerular filtration rate in diabetic children is elevated to the same extent as in adult short-term juvenile diabetics while the permeability of the glomerular membrane to macromolecules is normal. Interpretation of the results on intravascular albumin mass and transcapillary escape rate of albumin requires further investigation.This publication has 23 references indexed in Scilit:
- Precision of single injection [51Cr]EDTA plasma clearance and endogenous creatinine clearance determinations in childrenScandinavian Journal of Clinical and Laboratory Investigation, 1977
- Urinary Albumin Excretion during Exercise in Juvenile Diabetes a Provocation Test for Early AbnormalitiesScandinavian Journal of Clinical and Laboratory Investigation, 1975
- Urinary Albumin Excretion during Exercise in Juvenile Diabetes a Provocation Test for Early AbnormalitiesScandinavian Journal of Clinical and Laboratory Investigation, 1975
- Glomerular Filtration Rate and Extracellular Fluid Volumes during Normoglycemia and Moderate Hyperglycemia in DiabeticsScandinavian Journal of Clinical and Laboratory Investigation, 1973
- Abnormal Glomerular Filtration Rate, Renal Plasma Flow, and Renal Protein Excretion in Recent and Short-term DiabeticsBMJ, 1972
- Radioimmunoassay of β2-Microglobulin in Human Biological FluidsScandinavian Journal of Clinical and Laboratory Investigation, 1971
- Kidney Function and Glomerular Permeability to Macromolecules in Early Juvenile DiabetesScandinavian Journal of Clinical and Laboratory Investigation, 1971
- Glomerular Filtration Rate and Renal Plasma Flow in Short-term and Long-term Juvenile Diabetes MellitusScandinavian Journal of Clinical and Laboratory Investigation, 1971
- Radioimmunoassay for Urinary Albumin Using a Single AntibodyScandinavian Journal of Clinical and Laboratory Investigation, 1970
- Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of β2-microglobulin, albumin, and total proteinJCI Insight, 1969