Photopharmacology: Beyond Proof of Principle
Top Cited Papers
- 23 January 2014
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 136 (6), 2178-2191
- https://doi.org/10.1021/ja413063e
Abstract
Pharmacotherapy is often severely hindered by issues related to poor drug selectivity, including side effects, environmental toxicity, and the emergence of resistance. Lack of selectivity is caused by the inability to control drug activity in time and space. Photopharmacology aims at solving this issue by incorporating photoswitchable groups into the molecular structure of bioactive compounds. These switching units allow for the use of light as an external control element for pharmacological activity, which can be delivered with very high spatiotemporal precision. This Perspective presents the reader with the current state and outlook on photopharmacology. In particular, the principles behind photoregulation of bioactivity, the challenges of molecular design, and the possible therapeutic scenarios are discussed.This publication has 115 references indexed in Scilit:
- p-(4-Azipentyl)propofol: A Potent Photoreactive General Anesthetic Derivative of PropofolJournal of Medicinal Chemistry, 2011
- Tuning Photochromic Ion Channel BlockersACS Chemical Neuroscience, 2011
- Recent advances in the photochemical control of protein functionTrends in Biotechnology, 2010
- Light activation as a method of regulating and studying gene expressionCurrent Opinion in Chemical Biology, 2009
- Synergistic drug combinations tend to improve therapeutically relevant selectivityNature Biotechnology, 2009
- Efficient Drug Lead Discovery and OptimizationAccounts of Chemical Research, 2009
- How many drug targets are there?Nature Reviews Drug Discovery, 2006
- Molecular mechanisms of drug resistanceThe Journal of Pathology, 2005
- The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patientsEuropean Journal Of Cancer, 2004
- Enthalpies of formation of cis-azobenzene and trans-azobenzeneThe Journal of Chemical Thermodynamics, 1992