Isolated Tramadol Overdose Associated with Brugada ECG Pattern
- 7 October 2010
- journal article
- case report
- Published by Wiley in Pacing and Clinical Electrophysiology
- Vol. 35 (8), e219-e221
- https://doi.org/10.1111/j.1540-8159.2010.02924.x
Abstract
Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium‐channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium‐channel blockade. However, in vitro blockade of sodium‐channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2012; 35:e219–e221)Keywords
This publication has 15 references indexed in Scilit:
- Brugada-Pattern EKG in a Febrile PatientThe Journal of Emergency Medicine, 2007
- Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channelsPain, 2006
- Tramadol, but not its major metabolite (mono‐O‐demethyl tramadol) depresses compound action potentials in frog sciatic nervesBritish Journal of Pharmacology, 2006
- Brugada electrocardiographic pattern due to tricyclic antidepressant overdoseJournal of Electrocardiology, 2006
- Brugada Syndrome: Report of the Second Consensus ConferenceCell Metabolism, 2005
- The Postoperative Analgesic Effect of Tramadol When Used as Subcutaneous Local AnestheticAnesthesia & Analgesia, 2004
- Brugada Electrocardiographic Pattern Elicited by Inadvertent Flecainide OverdosePacing and Clinical Electrophysiology, 2004
- Brugada Pattern Electrocardiographic Changes Associated with Profound Electrolyte DisturbancePacing and Clinical Electrophysiology, 2004
- The Brugada syndrome: clinical, electrophysiologic and genetic aspectsJournal of the American College of Cardiology, 1999
- Propoxyphene-Induced Wide QRS Complex Dysrhythmia Responsive to Sodium Bicarbonate – A Case ReportJournal of Toxicology: Clinical Toxicology, 1995