Modulation of the anti-phosphorylcholine immune response duringTrichinella spiralisinfections in mice
- 1 December 1987
- journal article
- research article
- Published by Cambridge University Press (CUP) in Parasitology
- Vol. 95 (3), 583-592
- https://doi.org/10.1017/s0031182000058005
Abstract
The nematode Trichinella spiralis is able to modulate the antibody response, as measured by the plaque-forming cell (PFC) technique, to three thymus-dependent (TD) antigens: (1) a heterologous antigen unrelated to the parasite (sheep red blood cells (SRBC)); (2) an antigenic fraction, rich in phosphorylcholine (PC), obtained from T. spiralis (FCpl) and (3) a heterologous antigen unrelated to the parasite, but sharing the PC epitope with the FCpl fraction (PC-KLH). During the life-cycle of the parasite in BCF1 mice, two opposing immunomodulating activities occur: (1) an immuno-potentiating activity in mice infected during the intestinal and larval migratory stages, for all three antigens, and (2) a carrier-specific immunosuppressive response in mice infected and immunized with the FCpl fraction during the muscle phase of the life-cycle. The anti-PC PFC response of these mice is dependent on the infection dose and decreases from day 35 post-infection (p.i.) until at least day 85 p.i.. The factor responsible for the stimulating effect observed during this stage is the presence of migratory larvae in the host. All the foregoing seems to indicate that T. spiralis can use specific suppression mechanisms to aid in its own survival.This publication has 31 references indexed in Scilit:
- The antiphosphorylcholine plaque-forming cell responses induced by the nematode Trichinella in BWF1 miceMedical Microbiology and Immunology, 1987
- Effect of clofibrate and hydrocortisone on intestinal trichinellosis in miceVeterinary Parasitology, 1986
- Trichinella spiralis: Genetics of worm expulsion in inbred and F1 mice infected with different worm dosesExperimental Parasitology, 1984
- Immunomodulation by nematodes: A reviewVeterinary Parasitology, 1984
- Inbreeding and its Consequences, and the History of Inbred StrainsPublished by Springer Science and Business Media LLC ,1979
- Trichinella spiralis: Immunosuppression in challenge infections of Swiss miceExperimental Parasitology, 1977
- T-dependent suppression of the primary antibody response to sheep erythrocytes in mice infected with Trichinella spiralisCellular Immunology, 1976
- Immunological Sequelae of Trichinella spiralis Infection in Mice: Effect on the Antibody Responses to Sheep Erythrocytes and Japanese B Encephalitis VirusInfection and Immunity, 1975
- Selective immunodepression in mice by Trichinella spiralis extracts and infectionsCellular Immunology, 1975
- Phosphorylcholine‐bearing components in homogenates of nematodesEuropean Journal of Immunology, 1974