Light-Induced Changes in Pineal Hydroxyindole- O -Methyltransferase: Abolition by Lateral Hypothalamic Lesions
- 18 November 1966
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 154 (3751), 898-899
- https://doi.org/10.1126/science.154.3751.898
Abstract
The activity of hydroxyindole-O-methyltransferase, the melatoninforming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.This publication has 12 references indexed in Scilit:
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