Differential requirements for IL‐4/STAT6 signalling in CD4 T‐cell fate determination and Th2‐immune effector responses
- 15 December 2009
- journal article
- review article
- Published by Wiley in Immunology & Cell Biology
- Vol. 88 (3), 240-243
- https://doi.org/10.1038/icb.2009.101
Abstract
Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4(+) T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses.Keywords
Funding Information
- Health Research Council of New Zealand
- Marsden Fund
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