Comparison of Multiple Sclerosis Lesions at 1.5 and 3.0 Tesla
- 1 July 2003
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Investigative Radiology
- Vol. 38 (7), 423-427
- https://doi.org/10.1097/01.rli.0000065426.07178.f1
Abstract
To evaluate the relative sensitivity of MR scanning for multiple sclerosis (MS) at 1.5 Tesla (T) and 3.0 T using identical acquisition conditions, as is typical of multicenter clinical trials. Twenty-five subjects with MS were scanned at 1.5 T and 3.0 T using fast spin echo, and T(1)-weighted SPGR with and without gadolinium contrast injections. Image data, blinded to field strength, were analyzed using automated segmentation and lesion counting. Relative to scanning at 1.5 T, the 3.0 T scans showed a 21% increase in the number of detected contrast enhancing lesions, a 30% increase in enhancing lesion volume and a 10% increase in total lesion volume. The improved detection ability using high-field MR imaging is prominent even when sequence parameters are optimized around the midfield units. Multicenter trials using both 1.5 T and 3.0 T instruments may be affected by these sensitivity differences.Keywords
This publication has 34 references indexed in Scilit:
- Magnetic Resonance Diagnosis of the Anterior Labrum and CapsuleInvestigative Radiology, 1998
- Standing-wave and RF penetration artifacts caused by elliptic geometry: an electrodynamic analysis of MRIIEEE Transactions on Medical Imaging, 1998
- The Role of MRI in clinical trials of multiple sclerosis: Comparison of image processing techniquesAnnals of Neurology, 1997
- Intra- and inter-observer agreement of brain MRI lesion volume measurements in multiple sclerosisBrain, 1995
- Magnetic resonance imaging and spectroscopy in multiple sclerosisCurrent Opinion in Neurology, 1995
- Magnetic resonance imaging in the evaluation of clinical trials in multiple sclerosisAnnals of Neurology, 1994
- Rapid Automated Algorithm for Aligning and Reslicing PET ImagesJournal of Computer Assisted Tomography, 1992
- Field Strength in Neuro-MR ImagingJournal of Computer Assisted Tomography, 1990
- The field dependence of NMR imaging. II. Arguments concerning an optimal field strengthMagnetic Resonance in Medicine, 1986
- Rating neurologic impairment in multiple sclerosisNeurology, 1983