A COMPARISON OF THE EFFECTS OF 11-DESOXYCORTICOSTERONE ACETATE AND 17-HYDROXY-11-DEHYDRO-CORTICOSTERONE IN PARTIALLY DEPANCREATIZED RATS

Abstract

Partially depancreatized and adrenalectomized, and partially depancreatized rats were used to compare the physiological properties of 11-desoxy-corticosterone acetate and 17-hydroxy-ll-dehydro-corticosterone. Treatment with 1, 2 or 5 mg. of the latter compound was followed by glycosuria, ketonuria, an increase in the excretion of non-protein N, K and inorganic P, loss in wt. and ultimately resulted in the death of the animal. Treatment with equivalent quantities of 11-desoxy-corticosterone acetate failed to induce glycosuria, ketonuria or increased NP.N. excretion. A slight increase in K excretion, unaccompanied by an increased excretion of inorganic P, was noted following 11-desoxy-corticosterone acetate therapy. Larger doses of this compound (10 mg. daily) induced glycosuria in 2 of 3 animals so treated. In contrast to the effect of 17-hydroxy-ll-dehydro-cortico-sterone, treatment with 1, 2 or 5 mg. of 11-desoxycorticosterone acetate was followed by a striking decrease in the renal excretion of Na and Cl in 11 of 12 expts.