Advances in understanding of colorectal liver metastasis and implications for the clinic
- 18 July 2014
- journal article
- review article
- Published by Informa UK Limited in Expert Review of Gastroenterology & Hepatology
- Vol. 9 (2), 245-259
- https://doi.org/10.1586/17474124.2014.940897
Abstract
Colorectal cancer is one of the most common cancers in both the USA and Europe. Over the course of diagnosis, treatment and surveillance, up to 50% of these patients will develop metastases to their liver. In the past 20 years alone, there have been multiple advances in the management of these colorectal metastases to the liver. These advances have been made in characterization of these tumors, diagnosis and in treatment, both locally and systemically. Because of this progress, there are subsets of patients with this stage IV disease who are cured of their disease. While significant progress has been made, there still exist limitations in the management of metastatic colorectal cancer to the liver. This review outlines current strategies and highlights recent advances in the management of colorectal liver metastases.Keywords
This publication has 101 references indexed in Scilit:
- What is the most accurate whole-body imaging modality for assessment of local and distant recurrent disease in colorectal cancer? A meta-analysisEuropean Journal of Nuclear Medicine and Molecular Imaging, 2011
- CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progressionCancer and Metastasis Reviews, 2010
- Multi-centre phase II clinical trial of yttrium-90 resin microspheres alone in unresectable, chemotherapy refractory colorectal liver metastasesBritish Journal of Cancer, 2010
- Two-stage strategy for patients with extensive bilateral colorectal liver metastasesHPB, 2010
- Estimates of cancer incidence and mortality in Europe in 2008European Journal Of Cancer, 2010
- Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal CancerNew England Journal of Medicine, 2009
- Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choiceBritish Journal of Cancer, 2008
- Transcatheter Arterial Chemoembolization (TACE) in Hepatocellular Carcinoma (HCC): The Role of Angiogenesis and InvasivenessThe American Journal of Gastroenterology, 2008
- Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastasesBritish Journal of Surgery, 2007
- Factors influencing the natural history of colorectal liver metastasesThe Lancet, 1994