Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
- 22 December 2015
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 8 (408), ra130
- https://doi.org/10.1126/scisignal.aab0990
Abstract
Patient-specific modeling of a cell death–promoting pathway may lead to personalized treatment strategies.Keywords
Funding Information
- Breast Cancer Campaign UK (2013MaySP024)
- European Union Seventh Framework Programme (FP7/2007- 2013, FP7- HEALTH-2010-259348, FP7/2007-2013, FP-HEALTH-2011-278568)
- German Cancer Aid (110122)
- German Ministry of Science and Education (BMBF) (01ZX1303A, 01ZX1307D)
- Fordergesellschaft Kinderkrebs-Neuroblastom-Forschung
- Science Foundation Ireland (06/CE/B1129, 11/SIRG/B2157)
- Cancer Institute NSW (13/FRL/1-02)
This publication has 72 references indexed in Scilit:
- Pancreatic cancer genomes reveal aberrations in axon guidance pathway genesNature, 2012
- Comprehensive molecular portraits of human breast tumoursNature, 2012
- The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature, 2012
- Activated ALK Collaborates with MYCN in Neuroblastoma PathogenesisCancer Cell, 2012
- Global quantification of mammalian gene expression controlNature, 2011
- Strong negative feedback from Erk to Raf confers robustness to MAPK signallingMolecular Systems Biology, 2011
- COT drives resistance to RAF inhibition through MAP kinase pathway reactivationNature, 2010
- Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network DynamicsCell, 2010
- Multistrip Western Blotting to Increase Quantitative Data OutputPublished by Springer Science and Business Media LLC ,2009
- Rule-Based Modelling of Cellular SignallingLecture Notes in Computer Science, 2007