Intramolecular Hydroamination of Unactived Olefins with Ti(NMe2)4 as a Precatalyst
- 9 April 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (10), 1959-1962
- https://doi.org/10.1021/ol0503992
Abstract
Commercially available Ti(NMe2)4 has been used effectively as a precatalyst in a facile protocol for the intramolecular hydroamination of aminoalkenes to yield pyrrolidine and piperidine heterocyclic products with isolated yields up to 92%. Geminally substituted substrates display the highest reactivity. This precatalyst is also effective for the hydroamination of activated internal alkenes, providing access to more complex heterocyclic target molecules.Keywords
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