THE EFFECT OF ANOXEMIA IN NORMAL DOGS BEFORE AND AFTER DENERVATION OF THE CAROTID SINUSES

Abstract

A separation has been obtained between the respiratory responses to breathing N2 and CO2 in 4 normal dogs unaffected by anesthesia or acute operative procedures. By denervation of the carotid sinus regions the hyperpnea normally produced by breathing N2 was abolished. Thus the primary effect of anoxemia on the higher centers was obtained. This was generally a depression, the only excitatory change observed being a solitary gasp. The respiratory reaction of these dogs to CO2 was not abolished by denervation of the carotid sinus regions.