Antibiotics and Antibiotic Resistance Genes in Natural Environments
Top Cited Papers
- 18 July 2008
- journal article
- special perspectives
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 321 (5887), 365-367
- https://doi.org/10.1126/science.1159483
Abstract
The large majority of antibiotics currently used for treating infections and the antibiotic resistance genes acquired by human pathogens each have an environmental origin. Recent work indicates that the function of these elements in their environmental reservoirs may be very distinct from the “weapon-shield” role they play in clinical settings. Changes in natural ecosystems, including the release of large amounts of antimicrobials, might alter the population dynamics of microorganisms, including selection of resistance, with consequences for human health that are difficult to predict.Keywords
This publication has 29 references indexed in Scilit:
- Antibiotic-resistant soil bacteria in transgenic plant fieldsProceedings of the National Academy of Sciences, 2008
- The Neglected Intrinsic Resistome of Bacterial PathogensPLOS ONE, 2008
- Unexpected Occurrence of Plasmid-Mediated Quinolone Resistance Determinants in EnvironmentalAeromonasspp.Emerging Infectious Diseases, 2008
- Distribution and Physiology of ABC-Type Transporters Contributing to Multidrug Resistance in BacteriaMicrobiology and Molecular Biology Reviews, 2007
- Antibiotics as intermicrobial signaling agents instead of weaponsProceedings of the National Academy of Sciences, 2006
- Multidrug-resistance efflux pumps ? not just for resistanceNature Reviews Microbiology, 2006
- Sampling the Antibiotic ResistomeScience, 2006
- Agricultural Antibiotics and Human HealthPLoS Medicine, 2005
- SOS response promotes horizontal dissemination of antibiotic resistance genesNature, 2003
- The chromosomal 2'-N-acetyltransferase of providencia stuartii: physiological functions and genetic regulationFrontiers in Bioscience-Landmark, 1999