ADP‐induced Platelet Aggregation In Vitro in Patients with Ischemic Heart Disease and Peripheral Thromboatherosclerosis

Abstract

ADP-induced platelet aggregation in vitro has been studied in 90 normal controls and in 30 patients with ischemic heart disease (IHD) and 22 with peripheral thromboatherosclerosis (PTA). The sensitivity to ADP was defined by the threshold concentration which produced secondary aggregation with an amplitude corresponding to not less than 80% of the transmission obtained by platelet-poor plasma. In the normal controls the threshold concentration was significantly lower in women aged 50 or more than in women under that age. The geometric means were lower in the patients than in the controls. Significantly lower threshold concentrations than in the corresponding age groups of controls were found in the following age groups of patients: Men and women ≥50 years with IHD (p<0.005 and p<0.001, respectively), men and women under 50 with IHD (p<0.05). Men and women ≥50 years with PTA (p<0.002 and p<0.01, respectively), men and women under 50 with PTA (p<0.005).