Effect of glucose on food intake in hypothalamic hyperphagic rats.

Abstract

Intraperitoneal injections of 375 mg. of glucose and normal saline were given to hypothalamic hyperphagic rats and normal controls maintained on a 23 1/2-hr. deprivation schedule. Amount of food consumed in the 1/2 hr. beginning 15 min. after injection was determined. Under the 375-mg. glucose dosage food intake in the hyperphagic group was depressed 24.34% in comparison with the saline control level, while in the control group depression was 15.69%. With the 750-mg. dosage, depression in the hyperphagic group was 54.83%, and in the control group, 25.67%. Differences between groups were significant at both dosage levels. A possible explanation for the exaggerated anorexic effect of glucose in hyperphagic rats is suggested.