Nicotine: Effect on the Sleep Cycle of the Cat
- 29 October 1965
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 150 (3696), 637-638
- https://doi.org/10.1126/science.150.3696.637
Abstract
Small doses of nicotine (0.005 to 0.01 milligram per kilogram of body weight) given intravenously to sleeping cats with indwelling brain electrodes produce (i) initial electroen-cephalographic activation which was accompanied by behavioral arousal; (ii) a few minutes later, slow-wave sleep; and (iii) within 15 to 30 minutes, fast-wave sleep. Although peripheral afferent stimulation, release of epinephrine, and arginine vasopressin contribute to the initial arousal effects, the primary action of nicotine appears to be on the central nervous system.This publication has 4 references indexed in Scilit:
- Species differences in the eeg response to epinephrine, 5-hydroxytryptamine and nicotine in brainstem transected animalsInternational Journal of Neuropharmacology, 1963
- Action of nicotine on the ascending reticular activating systemInternational Journal of Neuropharmacology, 1962
- The occurence of low voltage, fast, electroencephalogram patterns during behavioral sleep in the catElectroencephalography and Clinical Neurophysiology, 1958
- Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreamingElectroencephalography and Clinical Neurophysiology, 1957