Surface Sulphydryl Groups and Hexose Monophosphate Pathway Activity in Resting Human Polymorphonuclear Leucocytes

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Abstract
Endotoxin [from Escherichia coli] taurocholic acid and concanavalin A stimulated [1-14C]glucose oxidation to a greater degree than [6-14C]glucose oxidation. The stimulation of glucose-1-C oxidation by endotoxin, taurocholic acid and concanavalin A could be prevented by p-chloromercuribenzene sulfonic acid, an inhibitor of surface sulfhydryl groups. In contrast, polymorphonuclear leukocytes from 4 patients with chronic granulomatous disease failed to show stimulation of glucose-1-C oxidation by endotoxin, taurocholic acid or concanavalin A.