Genetic Linkage Is Excluded for the D2-Dopamine Receptor λHD2Gl and Flanking Loci on Chromosome 11q22-q23 in Tourette Syndrome
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 40 (2), 105-108
- https://doi.org/10.1159/000153914
Abstract
A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ± 20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.Keywords
This publication has 5 references indexed in Scilit:
- The Inheritance of Gilles de la Tourette's Syndrome and Associated BehaviorsNew England Journal of Medicine, 1986
- DETECTION OF MAJOR GENE FOR GILLES-DE-LA-TOURETTE SYNDROME1984
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- Polymorphic DNA region adjacent to the 5' end of the human insulin gene.Proceedings of the National Academy of Sciences, 1981
- Analysis of human Y-chromosome-specific reiterated DNA in chromosome variants.Proceedings of the National Academy of Sciences, 1977