Studies in an animal model on the effectiveness of adjuvant chemotherapy with 5-FU and BCNU in cases of colorectal adenocarcinoma
- 1 June 1981
- journal article
- research article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 100 (2), 213-220
- https://doi.org/10.1007/bf00403367
Abstract
The effect of combined chemotherapy with 5-FU and BCNU on ten well differentiated human adenocarcinomas of different stages following xenotransplantation and growth in syngeneic balb/c nude mice collectives was investigated. With a tumor take of approximately 90%, it was found that marked remissions up to 43% of the original volume were only obtained with those transplant tumors initially classified as Dukes A and B; carcinomas graded Dukes C/D underwent no significant remission. Pathohistological findings during tumor remission revealed large amounts of fibrotic tissue together with surviving nests of tumor cells.Keywords
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