Ampicillin-Resistant Haemophilus influenzae Colonizing Ambulatory Children
- 1 May 1981
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Diseases of Children
- Vol. 135 (5), 406-409
- https://doi.org/10.1001/archpedi.1981.02130290004002
Abstract
• The prevalence of ampicillin sodium-resistant Haemophilus influenzae was determined from throat cultures of 305 ambulatory children. Resistant strains were detected in 3% of children, amounting to 12% of Haemophilus isolates. Factors associated with carriage of ampicillin-resistant strains were sought: only ampicillin exposure was significant. Among children who had received ampicillin or amoxicillin trihydrate within six months, 9% harbored ampicillin-resistant strains compared with 1.4% among those not exposed. Colonization with H influenzae was more frequent following the use of ampicillin, and a higher proportion of isolates was resistant (26% vs 6%). No effect on colonization or resistance rates was observed with other antibiotics or with factors such as age, sex, otitis history, or day-care center exposure. The association between ampicillin/amoxicillin usage and carriage of ampicillin-resistant strains is increasingly clear. It remains to be determined whether the use of newer antibiotics for otitis also will encourage the development of resistance in H influenzae. (Am J Dis Child 1981;135:406-409)This publication has 12 references indexed in Scilit:
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