Colcemid Sensitivity of Fission Yeast and the Isolation of Colcemid-Resistant Mutants
- 24 April 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3930), 485-487
- https://doi.org/10.1126/science.168.3930.485
Abstract
Cell division of the fission yeast, Schizosaccharomyces pombe, is reversibly inhibited by the antimitotic agent Colcemid (N-deacetyl-N-methylcolchicine) in nutrient medium. Cell growth continiues until all cells become nonseparating cell doublets in a V configuration. Mutants have been isolated capable of uninhibited growth in the presence of concentrations of Colcemid mycostatic for the parent strain.Keywords
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