SAFETY OF A FIFTH DOSE OF DIPHTHERIA AND TETANUS TOXOID AND ACELLULAR PERTUSSIS VACCINE IN CHILDREN EXPERIENCING EXTENSIVE, LOCAL REACTIONS TO THE FOURTH DOSE

Abstract

Extensive local reactions have been reported after booster doses of diphtheria and tetanus toxoid and acellular pertussis vaccine, but few data are available on revaccination after these reactions. Of 20 children with extensive local reactions after dose 4, only 4 experienced entire upper arm swelling and 7 had swelling >5 cm after dose 5. These reactions were well tolerated and support revaccination.

Keywords

This publication has 6 references indexed in Scilit:

Prophylaxis With Acetaminophen or Ibuprofen for Prevention of Local Reactions to the Fifth Diphtheria-Tetanus Toxoids-Acellular Pertussis Vaccination: A Randomized, Controlled Trial
Published by American Academy of Pediatrics (AAP) ,2006
Retrospective population-based assessment of medically attended injection site reactions, seizures, allergic responses and febrile episodes after acellular pertussis vaccine combined with diphtheria and tetanus toxoids
The Pediatric Infectious Disease Journal, 2002
Safety and immunogenicity of Biken acellular pertussis vaccine in combination with diphtheria and tetanus toxoid as a fifth dose at four to six years of age
The Pediatric Infectious Disease Journal, 2001
Safety and Immunogenicity of Six Acellular Pertussis Vaccines and One Whole-Cell Pertussis Vaccine Given as a Fifth Dose in Four- to Six-Year-Old Children
Pediatrics, 2000
Extensive Swelling After Booster Doses of Acellular Pertussis–Tetanus–Diphtheria Vaccines
Pediatrics, 2000
Reactogenicity and immunogenicity of a booster dose of a combined diphtheria, tetanus, and tricomponent acellular pertussis vaccine at fourteen to twenty-eight months of age
The Journal of Pediatrics, 1997

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