Testosterone Concentrations in Diabetic and Nondiabetic Obese Men
Open Access
- 3 March 2010
- journal article
- Published by American Diabetes Association in Diabetes Care
- Vol. 33 (6), 1186-1192
- https://doi.org/10.2337/dc09-1649
Abstract
OBJECTIVE To determine the prevalence of subnormal testosterone concentrations in patients with obesity and with type 2 diabetes in a primary care clinic population. RESEARCH DESIGN AND METHODS Free testosterone concentrations of 1,849 men (1,451 nondiabetic and 398 diabetic) in the Hypogonadism In Males (HIM) study were analyzed. The HIM study was a U.S.-based cross-sectional study designed to define the prevalence of hypogonadism in men aged >45 years. Free testosterone was measured by equilibrium dialysis. RESULTS The prevalence of subnormal free testosterone concentrations in lean, overweight, and obese nondiabetic men was 26% (n = 275), 29% (n = 687), and 40% (n = 489), respectively (P < 0.001 for trend), and 44% (n = 36), 44% (n = 135), and 50% (n = 227), respectively, in diabetic men (P = 0.46 for trend within group and P < 0.05 compared with nondiabetic men). The mean free testosterone concentration of diabetic men was significantly lower than that of nondiabetic men. Free testosterone concentrations were negatively and significantly (P < 0.001) related to age (r = −0.37), BMI (r = −0.18), and sex hormone–binding globulin (r = −0.11) in multiple regression analysis. The average decline of free testosterone concentrations was 7.8 pg/ml per decade in nondiabetic men and 8.4 pg/ml per decade in diabetic men. CONCLUSIONS Forty percent of obese nondiabetic men and 50% of obese diabetic men aged ≥45 years have subnormal free testosterone concentrations. In view of its high prevalence, obesity is probably the condition most frequently associated with subnormal free testosterone concentrations in males. The concomitant presence of diabetes is associated with an additional increase in the prevalence of subnormal free testosterone concentrations.Keywords
This publication has 26 references indexed in Scilit:
- Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and MenNew England Journal of Medicine, 2009
- Prevalence of hypogonadism in males aged at least 45 years: the HIM studyInternational Journal Of Clinical Practice, 2008
- Testosterone Concentration in Young Patients With DiabetesDiabetes Care, 2008
- Erectile dysfunction is associated with low bioactive testosterone levels and visceral adiposity in men with type 2 diabetesInternational Journal of Andrology, 2007
- The Effects of Hypogonadism on Body Composition and Bone Mineral Density in Type 2 Diabetic PatientsDiabetes Care, 2007
- Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 DiabetesDiabetes Care, 2007
- Androgens and Diabetes in MenDiabetes Care, 2007
- Contrasting Testosterone Concentrations in Type 1 and Type 2 DiabetesDiabetes Care, 2006
- Prevalence of Overweight and Obesity in the United States, 1999-2004JAMA, 2006
- Role of Brain Insulin Receptor in Control of Body Weight and ReproductionScience, 2000