Identification of the plasma membrane receptor for interleukin‐1 on mouse thymoma cells
- 27 July 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 219 (2), 365-368
- https://doi.org/10.1016/0014-5793(87)80254-5
Abstract
The plasma membrane receptor for interleukin‐1 (IL‐1) has been characterized from mouse EL4‐6.1 thymoma cells. Following binding of IL‐1 to surface labeled EL4‐6.1 cells, the IL‐1 binding molecule was immunoprecipitated using a rabbit antiserum against the hormone. The putative IL‐1 receptor is a membrane‐associated glycopeptide of Mr = 82000 containing probably two or three N‐linked glycan units as indicated by its conversion into a Mr = 60 000 polypeptide upon deglycosylation with endo‐β‐N‐glycosidase F.Keywords
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