Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer
Open Access
- 22 January 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 98 (3), 627-632
- https://doi.org/10.1038/sj.bjc.6604192
Abstract
The relationship between expression of the inhibitor of apoptosis protein survivin and the presence of high-risk human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OSCC) remains unclear. This also accounts for its role as a predictor of survival. Therefore, we conducted a multicentre retrospective study on 106 consecutive oropharyngeal cancer patients. Human papillomavirus sequences were detected by nested PCR protocols. Survivin and p16 expression as a surrogate marker for HPV status were analysed by immunohistochemistry. Sequences of high-risk HPV were detected in 29% of cases. Prominent cytoplasmatic expression of survivin was found in 58% of cases and nuclear expression of survivin was found in 19% of the survivin-positive tumours. Nuclear expression of survivin was significantly correlated with HPV-negative tumours (P=0.023) and with a poor disease-free survival rate with an estimated 3-year disease-free survival probability of 35% for tumours with nuclear expression of survivin vs 78% for tumours with non-nuclear expression of survivin (hazard ratio=8.264; 95% confidence interval (95% CI)=2.510–27.210; PP=0.041 and hazard ratio=15.975; 95% CI=2.377–107.360; P=0.004, respectively). Our data show that nuclear accumulation of survivin correlates with HPV-independent carcinogenesis and is an independent predictor of poor survival in patients with OSCC.This publication has 43 references indexed in Scilit:
- Effects of human papillomavirus type 16 oncoproteins on survivin gene expressionJournal of General Virology, 2006
- Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic ReviewCancer Epidemiology, Biomarkers & Prevention, 2005
- Nuclear localization of survivin is a positive prognostic factor for survival in advanced non-small-cell lung cancerAnnals Of Oncology, 2004
- Human papillomavirus-positive tonsillar carcinomas: a different tumor entity?Medical Microbiology and Immunology, 2003
- Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsilInternational Journal of Cancer, 2003
- Regulating Access to the GenomeCell, 2003
- The INK4a/ARF network in tumour suppressionNature Reviews Molecular Cell Biology, 2001
- Human papillomavirus positive squamous cell carcinoma of the oropharynxCancer, 2001
- Human papillomavirus (HPV) DNA in tonsillar cancer: Clinical correlates, risk of relapse, and survivalInternational Journal of Cancer, 2000
- Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicksInternational Journal of Cancer, 1968