The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults
Open Access
- 28 February 2013
- journal article
- Published by Springer Science and Business Media LLC in BMC Geriatrics
- Vol. 13 (1), 21
- https://doi.org/10.1186/1471-2318-13-21
Abstract
Aging and physical inactivity are associated with declines in some cognitive domains and cerebrovascular function, as well as an elevated risk of cerebrovascular disease and other morbidities. With the increase in the number of sedentary older Canadians, promoting healthy brain aging is becoming an increasingly important population health issue. Emerging research suggests that higher levels of physical fitness at any age are associated with better cognitive functioning and this may be mediated, at least in part, by improvements in cerebrovascular reserve. We are currently conducting a study to determine: if a structured 6-month aerobic exercise program is associated with improvements or maintenance of both cerebrovascular function and cognitive abilities in older individuals; and, the extent to which any changes seen persist 6 months after the completion of the structured exercise program.Keywords
This publication has 58 references indexed in Scilit:
- Mechanisms of Age-Related Cognitive Change and Targets for Intervention: Social Interactions and StressThe Journals of Gerontology: Series A, 2012
- Exercise, brain, and cognition across the life spanJournal of Applied Physiology, 2011
- Exercise training increases size of hippocampus and improves memoryProceedings of the National Academy of Sciences, 2011
- Brain fuel metabolism, aging, and Alzheimer’s diseaseNutrition, 2011
- Physical Activity Over the Life Course and Its Association with Cognitive Performance and Impairment in Old AgeJournal of the American Geriatrics Society, 2010
- Neural mechanisms of ageing and cognitive declineNature, 2010
- Promising Strategies for the Prevention of DementiaArchives of Neurology, 2009
- Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older womenNeurobiology of Aging, 2008
- Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageingThe Journal of Physiology, 2008
- Cardiorespiratory fitness and brain atrophy in early Alzheimer diseaseNeurology, 2008