Skeletal muscle proteomics: current approaches, technical challenges and emerging techniques
Open Access
- 1 January 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Skeletal Muscle
- Vol. 1 (1), 6
- https://doi.org/10.1186/2044-5040-1-6
Abstract
Skeletal muscle fibres represent one of the most abundant cell types in mammals. Their highly specialised contractile and metabolic functions depend on a large number of membrane-associated proteins with very high molecular masses, proteins with extensive posttranslational modifications and components that exist in highly complex supramolecular structures. This makes it extremely difficult to perform conventional biochemical studies of potential changes in protein clusters during physiological adaptations or pathological processes.Keywords
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