EFFECTS OF EXTRACTS OF THE HYPOPHYSIS, THE THYROID AND THE ADRENAL CORTEX ON SOME RENAL FUNCTIONS

Abstract

Subcut. administered extracts of the glandular hypophysis increased the diodrast and inulin clearances and the maximum excretion of diodrast at high plasma levels in normal, in simple hypophysectomy, in total hypophysectomy and in "puncture" dogs, i.e., those with a hypothalamic lesion of a type causing diabetes insipidus and obesity. Orally administered thyroid extract caused a similar though less marked increase in the above renal functions. Subcut. administered adrenal cortical extract did not increase but tended rather to decrease diodrast clearance in normal, in simple hypophysectomy and in totally hypophysectomized dogs. It increased diodrast clearance in the hypothalamic puncture dog. Inulin clearance in normal, in simple and in total hypophysectomy dogs usually was decreased by it but occasionally there was a moderate increase believed due to constriction of the glomerular arterioles. It increased diodrast and inulin clearances in the hypothalamic puncture dog. Diodrast Tm was decreased in the normal and in all the types of exptl. dogs studied. The results are inter-preted as indicating that in normal, in simple and in total hypophysectomized dogs ant. lobe extract and thyroid extract increase renal blood flow and also increase the capacity of the renal tubules to transport diodrast at high plasma levels. Adrenal cortical extract does not increase, probably decreases renal blood flow slightly. It does not increase the capacity of the renal tubules to transport diodrast at high plasma levels.