Hematopoietic Transcriptional Regulation by the Myeloid Zinc Finger Gene, MZF-1
- 1 January 1996
- book chapter
- review article
- Published by Springer Science and Business Media LLC
- Vol. 211, 159-164
- https://doi.org/10.1007/978-3-642-85232-9_16
Abstract
Transcriptional regulators control much of hematopoiesis. One such transcriptional regulator is the myeloid zinc finger gene MZF-1. MZF-1 has been localized to the telomere of chromosome 19q, where a large number of related zinc finger genes reside. It has been found to be essential in granulopoiesis. It is a bi-functional transcriptional regulator, repressing transcription in non-hematopoietic cells, and activating transcription in cells of hematopoietic origins. Its consensus DNA binding site has been isolated, and sites in several promoters of myeloid-specific genes, such as CD34, lactoferrin, and myeloperoxidase, have been defined. In co-transfection experiments MZF-1 has been found to regulate transcription from the CD34 promoter.Keywords
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