Dipeptide Antagonists of Amino Acid‐Induced and Synaptic Excitation in the Frog Spinal Cord
- 1 December 1980
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 35 (6), 1458-1460
- https://doi.org/10.1111/j.1471-4159.1980.tb09025.x
Abstract
The dipeptide gamma-D-glutamylglycine (gamma DGG) antagonizes amino acid-induced depolarization and synaptic excitation in the isolated hemisected spinal cord of the frog. In general, the effects of this compound resembled those of the structurally similar D-alpha-aminosuberate (D alpha AS) in being more effective against N-methyl-D-aspartate (NMDA)-induced responses than against responses induced by other excitatory amino acids. However gamma DGG appeared to be more effective than D alpha AS in depressing kainate-induced responses. Similar, though weaker, effects were produced by the L isomer of the dipeptide (gamma LGG), a natural brain constituent.Keywords
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