Cartilage morphogenetic proteins: role in joint development, homoeostasis, and regeneration
- 1 November 2003
- journal article
- review article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 62 (90002), 73ii-78
- https://doi.org/10.1136/ard.62.suppl_2.ii73
Abstract
Articular cartilage homoeostasis is critical for joint function. The steady state homoeostasis of articular cartilage is a balance between anabolic morphogens such as cartilage derived morphogenetic proteins (CDMPs) and bone morphogenetic proteins (BMPs) of the BMP family and catabolic cytokines such as interleukin (IL)1, IL17, and tumour necrosis factor alpha. Although bone and articular cartilage are adjacent tissues, there is a profound difference in their regeneration potential. Bone has the highest potential for regeneration. On the other hand, articular cartilage is recalcitrant to repair. To examine the hypothesis that the feeble innate regeneration ability of cartilage is due to the preponderance of catabolic cytokines such as IL1 and IL17. During a systematic investigation of CDMPs and cytokines IL17B (chondroleukin) was found in bovine articular cartilage. BMP-7 and IL17B are present in articular cartilage and synthesised in chondrocytes as shown by northern blots and real-time reverse transcription-polymerase chain reaction. The coexistence of anabolic morphogens and catabolic cytokines in articular cartilage has important implications for cartilage homoeostasis and regeneration. The networks of signalling systems of morphogens and cytokines determine the net capacity for regenerative morphogenesis of articular cartilage. Finally, the feeble innate capacity for articular cartilage may be improved by targeted therapy by soluble receptors to block catabolic cytokines.Keywords
This publication has 68 references indexed in Scilit:
- A human chondrodysplasia due to a mutation in a TGF-β superfamily memberNature Genetics, 1996
- Cartilage morphogenesis: Role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrixMatrix Biology, 1995
- The long and short of hedgehog signalingCell, 1995
- Human COL2A1-directed SV40 T antigen expression in transgenic and chimeric mice results in abnormal skeletal development.The Journal of cell biology, 1995
- Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamilyNature, 1994
- Localization of Osteogenic Protein-1 (Bone Morphogenetic Protein-7) during Human Embryonic Development: High Affinity Binding to Basement MembranesBiochemical and Biophysical Research Communications, 1994
- Type II Collagen Mutations in Rare and CommonAnnals of Medicine, 1994
- Light microscopic characterization of the fibroblast‐like synovial intimal cell (synoviocyte)Arthritis & Rheumatism, 1992
- Osteogenin (bone morphogenetic protein-3) stimulates cartilage formation by chick limb bud cells in vitroDevelopmental Biology, 1991
- Hypertrophic ChondrocytesAnnals of the New York Academy of Sciences, 1990