Spontaneous Diabetes Mellitus: Reversal and Prevention in the BB/W Rat with Antiserum to Rat Lymphocytes
- 21 December 1979
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 206 (4425), 1421-1423
- https://doi.org/10.1126/science.388619
Abstract
Injections of rabbit antiserum to rat lymphocytes reversed hyperglycemia in 36 percent of spontaneously diabetic rats (Bio Breeding/Worcester) and prevented diabetes in susceptible nondiabetic controls. These findings strengthen the hypothesis that cell-mediated autoimmunity plays a role in the pathogenesis of diabetes in this animal model that mimics many morpholigic and physiologic characteristics of human insulin-dependent diabetes mellitus.Keywords
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