Postoperative Infliximab Is Not Associated with An Increase in Adverse Events in Crohn’s Disease
- 17 June 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Digestive Diseases and Sciences
- Vol. 56 (12), 3610-3615
- https://doi.org/10.1007/s10620-011-1785-9
Abstract
Infliximab is effective treatment for Crohn’s disease and has been associated with rare, but serious infectious complications. Emerging data suggest a benefit of infliximab in preventing postoperative Crohn’s disease recurrence. It is not known whether administration of infliximab shortly after resective surgery for Crohn’s disease increases postoperative complications. To evaluate the risk of developing postoperative complications among Crohn’s disease patients receiving infliximab within 4 weeks of intestinal resection. As part of a randomized placebo-controlled infliximab postoperative prevention study, adverse events were prospectively monitored. Crohn’s disease patients undergoing intestinal resection were randomized to placebo or infliximab 2–4 weeks after surgery. Study infusions were administered at 0, 2, and 6 weeks then every 8 weeks for 1 year. To evaluate whether infliximab increased postoperative complications, we analyzed all adverse events for 1 year after surgery. Twenty-four patients were randomized to infliximab or placebo after intestinal resection for Crohn’s disease. Mean time to first postoperative infusion was 20 days (range 14–25 days). Over the course of 1 year, there were 22 total adverse events, but no difference between infliximab and placebo patients (12 versus 10, respectively, P = 1.0). In the immediate postoperative period, within 8 weeks of surgery, the number of adverse events was also similar between the two groups (3 infliximab and 5 placebo patients, P = 0.68). There were no serious adverse events and no complications related to wound healing or infection. Initiation of infliximab within 4 weeks of intestinal resection was not associated with postoperative complications.Keywords
This publication has 21 references indexed in Scilit:
- W1291 Adalimumab in the Prevention of Postoperative Recurrence of Crohn's DiseaseGastroenterology, 2010
- Postoperative Crohn’s disease: prevention and treatmentExpert Review of Gastroenterology & Hepatology, 2009
- Infliximab Prevents Crohn's Disease Recurrence After Ileal ResectionGastroenterology, 2009
- Infliximab With Low-Dose Methotrexate for Prevention of Postsurgical Recurrence of Ileocolonic Crohn DiseaseArchives of Internal Medicine, 2007
- Review article: recurrence of Crohn's disease after surgery – the need for treatment of new lesionsAlimentary Pharmacology & Therapeutics, 2006
- Serious Infections and Mortality in Association With Therapies for Crohn’s Disease: TREAT RegistryClinical Gastroenterology and Hepatology, 2006
- Effects of Perioperative Antiinflammatory and Immunomodulating Therapy on Surgical Wound HealingPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2005
- Inhibition of tumor necrosis factor‐α attenuates wound breaking strength in ratsWound Repair and Regeneration, 2000
- Natural course of Crohn's disease after ileocolic resection: endoscopically visualised ileal ulcers preceding symptoms.Gut, 1992
- Primary and Recurrent Crohnʼs DiseaseAnnals of Surgery, 1991