Depression of Hepatic Microsomal Enzyme Systems by Lentinan in Mice
Open Access
- 1 January 1985
- journal article
- research article
- Published by Elsevier BV in The Japanese Journal of Pharmacology
- Vol. 37 (1), 107-115
- https://doi.org/10.1254/jjp.37.107
Abstract
Studies were performed to determine the effects of an immunopotentiating agent, lentinan, on the hepatic drug-metabolizing enzymes in mice. Lentinan was injected twice a day for 2 days, and the enzyme activities were determined 12 h after the last injection of lentinan. A lentinan dose of over 0.25 mg/kg was required to cause a significant decrease (20-40%) in the hepatic microsomal aminopyrine N-demethylase and aniline hydroxylase activities. The loss of drug-metabolizing activity by the treatment with lentinan agreed with the loss of cytochrome P-450 content in many cases. Strain and substrate differences concerning the effect of lentinan on the metabolism of drug were also observed. The loss of cytochrome P-450 content by the treatment with lentinan was observed in the ddY, C57BL/6 and BDF1 strain mice, but was not observed in the DBA/2, C3H/He and C57BL/10 strain mice. The decrease in the activities of 7-ethoxycoumarin O-deethylase and biphenyl 2-hydroxylase by the treatment with lentinan was considerably less than that of aminopyrine N-demethylase and aniline hydroxylase in ddY mice. [This may have a significant effect in the metabolism of other drugs.].Keywords
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