Hybridoma Produces Protective Antibodies Directed Against the Sporozoite Stage of Malaria Parasite
- 4 January 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4426), 71-73
- https://doi.org/10.1126/science.6985745
Abstract
Hybrid cells secreting antibodies against sporozoites of Plasmodium berghei were obtained by fusion of plasmacytoma cells with immune murine spleen cells. The monoclonal antibodies bound to a protein with an apparent molecular weight of 44,000 (Pb44), which envelopes the surface membrane of sporozoites. Incubation of sporozoites in vitro with antibodies to Pb44 abolished their infectivity.Keywords
This publication has 11 references indexed in Scilit:
- Antibodies to Sporozoites: Their Frequent Occurrence in Individuals Living in an Area of Hyperendemic MalariaScience, 1979
- Stage-specific antigens on the surface membrane of sporozoites of malaria parasitesNature, 1978
- Characterisation of the surface coat of Trypanosoma congolenseNature, 1978
- Diazoniobenzenesulfonate as Marker for Cell Surface Proteins: Study of the Surface Coat ofTrypanosoma congolenseHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1978
- Identification, purification and properties of clone-specific glycoprotein antigens constituting the surface coat ofTrypanosoma bruceiParasitology, 1975
- Rapid Isolation of Antigens from Cells with A Staphylococcal Protein A-Antibody Adsorbent: Parameters of the Interaction of Antibody-Antigen Complexes with Protein AJournal Of Immunology, 1975
- Continuous cultures of fused cells secreting antibody of predefined specificityNature, 1975
- THE ENZYMATIC IODINATION OF THE RED CELL MEMBRANEThe Journal of cell biology, 1972
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- Protective Immunity Produced by the Injection of X-Irradiated Sporozoites of Plasmodium bergheiMilitary Medicine, 1969