Ultrastructural study of a mucinous carcinoid of the skin
- 27 April 1991
- journal article
- case report
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 18 (2), 128-133
- https://doi.org/10.1111/j.1600-0560.1991.tb00140.x
Abstract
A tumor of 60 years' duration overlying the sternum of an 87‐year‐old woman is described. Histologically, the tumor was composed of lobules and cords of epithelial cells with finely granular, eosinophilic cytoplasm. The epithelial nests were floating in large pools of mucinous stroma, separated by thin fibro‐vascular septa. Cytoplasmic argyrophilia was seen by Grimelius silver stain. Positive reactions of the tumor cells were also found for chromogranin and neuron‐specific enolase. Ultrastructural study revealed that the cytoplasm of the tumor cells contained two types of granules: neurosecretory and mucinous. From these findings, the present tumor is considered to be a carcinoid tumor with amphicrine cells, and the term ‘mucinous carcinoid’ of the skin seems to be appropriate for the diagnosis of the present case.Keywords
This publication has 26 references indexed in Scilit:
- An immunohistoiogic study on eccrine gland carcinomaJournal of the American Academy of Dermatology, 1989
- Eccrine and Squamous Differentiation in Merkel Cell CarcinomaThe American Journal of Surgical Pathology, 1988
- Immunohistochemical demonstration of simple epithelia-type keratin intermediate filament in a case of Merkel cell carcinomaArchives of Dermatology, 1987
- Amphicrine — Composite Calcitonin and Mucin-Producing — Carcinoma of the ThyroidUltrastructural Pathology, 1985
- Sweat gland tumor with glandular and spindle cell featuresArchives of Dermatology, 1983
- Primary Polypeptide Hormones and Mucin-Producing Malignant Carcinoid of the LarynxUltrastructural Pathology, 1983
- Unusual cutaneous carcinoma with features of small cell (oat cell-like) and squamous cell carcinomasThe American Journal of Dermatopathology, 1982
- Endocrine‐paracrine cells in pancreatic exocrine carcinomasHistopathology, 1981
- Endocrine differentiation in mucoid carcinoma of the breastHistopathology, 1980
- THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPYThe Journal of cell biology, 1963