9‐Fluorenylmethyl esters
- 1 February 1983
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 21 (2), 196-201
- https://doi.org/10.1111/j.1399-3011.1983.tb03093.x
Abstract
N alpha-Protected amino acid 9-fluorenylmethyl esters (Fm esters) were prepared by imidazole-catalyzed transesterification of active esters with 9-fluorenylmethanol (9-hydroxymethylfluorene). The new carboxyl protection is unaffected by acids, but is efficiently removed by beta-elimination under the influence of secondary and tertiary amines. Primary amines and ammonia can cause slight amide formation. Deblocking was achieved also by catalytic hydrogenation.Keywords
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