INHIBITION OF OVULATION IN THE RABBIT BY THE ADRENERGIC-BLOCKING AGENT DIBENAMINE
- 1 November 1947
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 41 (5), 395-402
- https://doi.org/10.1210/endo-41-5-395
Abstract
25-32 mg./kg. of Dibenamine, given intraven. within 1 min. after the end of copulation, prevented ovulation in 16 of 19 animals. The same doses of Dibenamine were ineffective if injn. was delayed for 3 mins. or more following coitus. These expts. support the hypothesis that ovulation in the rabbit is dependent upon a humoral pathway of an adrenergic nature, and indicate that the necessary stimulation of the hypophysis is completed within little more than 1 min. following copulation. Priscol was found to be ineffective in preventing ovulation following coitus.Keywords
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