Et2Zn-Catalyzed Intramolecular Hydroamination of Alkynyl Sulfonamides and the Related Tandem Cyclization/Addition Reaction
- 20 June 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 72 (15), 5731-5736
- https://doi.org/10.1021/jo070681h
Abstract
Intramolecular hydroamination of alkynyl amides was effected by a catalytic amount of Et2Zn (20 mol %) to form indole derivatives, and a tandem cyclization/nucleophilic addition procedure involving reaction of the indole zinc salt intermediate with acid chlorides or halides was developed to provide an efficient approach to C3-substituted indole derivatives when an excess of Et2Zn (120 mol %) was used.Keywords
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