ppGpp Conjures Bacterial Virulence
- 1 June 2010
- journal article
- review article
- Published by American Society for Microbiology in Microbiology and Molecular Biology Reviews
- Vol. 74 (2), 171-199
- https://doi.org/10.1128/mmbr.00046-09
Abstract
SUMMARY: Like for all microbes, the goal of every pathogen is to survive and replicate. However, to overcome the formidable defenses of their hosts, pathogens are also endowed with traits commonly associated with virulence, such as surface attachment, cell or tissue invasion, and transmission. Numerous pathogens couple their specific virulence pathways with more general adaptations, like stress resistance, by integrating dedicated regulators with global signaling networks. In particular, many of nature's most dreaded bacteria rely on nucleotide alarmones to cue metabolic disturbances and coordinate survival and virulence programs. Here we discuss how components of the stringent response contribute to the virulence of a wide variety of pathogenic bacteria.Keywords
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