Age at Graft Loss after Pediatric Kidney Transplantation
Open Access
- 1 June 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 8 (6), 1019-1026
- https://doi.org/10.2215/cjn.10311012
Abstract
Background and objective The risk of graft loss after pediatric kidney transplantation increases during late adolescence and early adulthood, but the extent to which this phenomenon affects all recipients is unknown. This study explored interactions between recipient factors and this high-risk age window, searching for a recipient phenotype that may be less susceptible during this detrimental age interval. Design, setting, participants, & measurements With use of Scientific Registry of Transplant Recipients data from 1987 to 2010, risk of graft loss across recipient age was quantified using a multivariable piecewise-constant hazard rate model with time-varying coefficients for recipient risk factors. Results Among 16,266 recipients, graft loss during ages ≥17 and PPConclusions No recipient subgroups are exempt from the dramatic increase in graft loss during late adolescence and early adulthood, a high-risk window that modifies the relationship between typical recipient risk factors and graft loss.Keywords
This publication has 24 references indexed in Scilit:
- Association Between Age and Graft Failure Rates in Young Kidney Transplant RecipientsTransplantation, 2011
- Kidney transplant survival in pediatric and young adultsBMC Nephrology, 2011
- Transition from pediatric to adult renal services: a consensus statement by the International Society of Nephrology (ISN) and the International Pediatric Nephrology Association (IPNA)Pediatric Nephrology, 2011
- Medical adherence in pediatric organ transplantationCurrent Opinion in Organ Transplantation, 2011
- Graft Failure and Adaptation Period to Adult Healthcare Centers in Pediatric Renal Transplant PatientsTransplantation, 2011
- Meta-Analysis of Medical Regimen Adherence Outcomes in Pediatric Solid Organ TransplantationTransplantation, 2009
- Adherence to the immunosuppressive regimen in pediatric kidney transplant recipients: A systematic reviewPediatric Transplantation, 2009
- Health insurance considerations for adolescent transplant recipients as they transition to adulthoodPediatric Transplantation, 2006
- Pediatric transplantation, 1994–2003American Journal of Transplantation, 2005
- Pediatric transplantationAmerican Journal of Transplantation, 2004