Association of Platelet-Activating Factor with Primary Acquired Cold Urticaria
- 15 August 1985
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 313 (7), 405-409
- https://doi.org/10.1056/nejm198508153130702
Abstract
We investigated the possibility that the inflammatory reaction in primary acquired cold urticaria might be associated with the release of platelet-activating factor. Six patients with the disease and five normal controls were subjected to cold-water challenges during which blood samples were obtained for measurement of the release of possible mediators: i.e., histamine, neutrophilic chemotactic activity, and platelet-activating factor-like lipid (PAFLL). Four of the patients had pronounced experimentally induced cold urticaria with angioedema and release of mediators. Levels of the three mediators were not elevated in five normal controls or in two patients in whom cold challenges induced only mild urticaria and angioedema. The effective suppression of cold-induced urticaria in three patients treated with doxepin correlated with inhibition of PAF-LL release but not inhibition of histamine or neutrophilic chemotactic activity release. These data suggest a positive correlation between PAF-LL release and cold urticaria, although the exact relation between PAF-LL and cutaneous lesions of primary acquired cold urticaria has not yet been established. (N Engl J Med 1985; 313: 405–9.)This publication has 31 references indexed in Scilit:
- Release of platelet factor 4 into the blood after cold challenge of patients with cold urticariaJournal of Allergy and Clinical Immunology, 1984
- Inflammatory characteristics of platelet activating factor (PAF-acether) in human skinBritish Journal of Dermatology, 1984
- Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophilsBiochimica et Biophysica Acta (BBA) - General Subjects, 1980
- Antihypertensive activity of an alkyl ether analog of phosphatidylcholineBiochemical and Biophysical Research Communications, 1979
- The role of platelet-activating factor in platelet aggregationNature, 1979
- Cold UrticariaJCI Insight, 1977
- In vivo studies of mediator release in cold urticaria and cholinergic urticariaJournal of Allergy and Clinical Immunology, 1975
- LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETSThe Journal of Experimental Medicine, 1972
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959
- Studies on blood histamine in cases of allergy: I. Blood histamine during wheal formationJournal of Allergy, 1941