Acute Splenic Sequestration Crises (ASSC) in Young Children with Sickle Cell Anemia
- 1 December 1972
- journal article
- other
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 11 (12), 701-704
- https://doi.org/10.1177/000992287201101214
Abstract
Acute splenic sequestration crises (ASSC) is a potentially life-threatening com plication in young children with sickle cell anemia. The clinical picture includes huge splenomegaly accompanied by signs and symptoms of acute circulatory insufficiency caused by profound anemia. The authors describe 20 such episodes in 14 children aged six to 55 months. Rapid transfusion of packed erythrocytes produced rapid and dramatic improvement. The spleens became nonpalpable in seven to ten days following transfusion. Four children died, four had one or more recurrences, four have splenic involution, and two were splenectomized. The recurrences were within four months of the previous ASSC. "Our current recommendation is to consider splenectomy only after at least two ASSCs."Keywords
This publication has 3 references indexed in Scilit:
- HEMOGLOBIN S‐THALASSEMIA SYNDROME IN NEGRO CHILDREN1Annals of the New York Academy of Sciences, 1969
- Sickle cell anemia in the first 2 years of lifeThe Journal of Pediatrics, 1961
- Studies in sickle cell anemia: XVI. Sudden death during sickle cell anemia crises in young childrenThe Journal of Pediatrics, 1960