Long-Term Potentiation and Memory
Top Cited Papers
- 1 January 2004
- journal article
- review article
- Published by American Physiological Society in Physiological Reviews
- Vol. 84 (1), 87-136
- https://doi.org/10.1152/physrev.00014.2003
Abstract
Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004; 10.1152/physrev.00014.2003.—One of the most significant challenges in neuroscience is to identify the cellular and molecular processes that underlie learning and memory formation. The past decade has seen remarkable progress in understanding changes that accompany certain forms of acquisition and recall, particularly those forms which require activation of afferent pathways in the hippocampus. This progress can be attributed to a number of factors including well-characterized animal models, well-defined probes for analysis of cell signaling events and changes in gene transcription, and technology which has allowed gene knockout and overexpression in cells and animals. Of the several animal models used in identifying the changes which accompany plasticity in synaptic connections, long-term potentiation (LTP) has received most attention, and although it is not yet clear whether the changes that underlie maintenance of LTP also underlie memory consolidation, significant advances have been made in understanding cell signaling events that contribute to this form of synaptic plasticity. In this review, emphasis is focused on analysis of changes that occur after learning, especially spatial learning, and LTP and the value of assessing these changes in parallel is discussed. The effect of different stressors on spatial learning/memory and LTP is emphasized, and the review concludes with a brief analysis of the contribution of studies, in which transgenic animals were used, to the literature on memory/learning and LTP.Keywords
This publication has 102 references indexed in Scilit:
- Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genisteinHippocampus, 2002
- Long-term potentiation of single subicular neurons in miceHippocampus, 2000
- BDNF Protects against Spatial Memory Deficits Following Neonatal Hypoxia-IschemiaExperimental Neurology, 2000
- MAP kinase-mediated signalling to nucleosomes and immediate-early gene inductionSeminars in Cell & Developmental Biology, 1999
- Analysis of the interaction between arachidonic acid and metabotropic glutamate receptor activation reveals that phospholipase C acts as a coincidence detector in the expression of long-term potentiation in the rat dentate gyrusHippocampus, 1998
- LTP and spatial learning?Where to next?Hippocampus, 1997
- Aging-related increase in hippocampal calcium channelsLife Sciences, 1996
- The cyclic AMP system andDrosophila learningMolecular and Cellular Biochemistry, 1995
- Spatial learning and the saturation of long‐term potentiationHippocampus, 1993
- Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal areaJournal of Neurocytology, 1977