Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR
Open Access
- 27 August 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Radiology
- Vol. 22 (1), 221-231
- https://doi.org/10.1007/s00330-011-2242-z
Abstract
To examine the feasibility and value of 7 T 3D T2-weighted Fluid Attenuated Inversion Recovery (FLAIR) and Double Inversion Recovery (DIR) MR sequences for lesion detection in multiple sclerosis (MS). High-resolution 3D-FLAIR and 3D-DIR MR sequences at 7 T were obtained using magnetisation preparation (MP), and compared with 2D-T2-weighted and 3D-T1-weighted sequences in 10 MS patients and five healthy controls. We determined contrast ratios and counted lesions according to anatomical location. MR imaging at 7 T was safe and allowed multi-contrast imaging within clinically acceptable imaging times. Lesion to white matter (WM) and grey matter (GM) contrast ratios were higher in 3D-MP-FLAIR and 3D-MP-DIR compared with 2D-T2 and 3D-T1. Cortical (mixed+intra-cortical) and total lesion counts were 97/592 on 3D-MP-FLAIR and 100/558 on 3D-MP-DIR compared with 84/384 on 2D-T2 and 42/442 on 3D-T1. More juxta-cortical lesions were seen with 3D-MP-FLAIR (205) and 3D-MP-DIR (133) than with 2D-T2 (125) and 3D-T1 (70). Finally, higher numbers of lesions were found for deep WM lesions: 176 for 3D-MP-FLAIR and 196 for 3D-MP-DIR vs. 155 for 2D-T2 and 131 for 3D-T1. Near isotropic 3D-MP-FLAIR and 3D-MP-DIR allows high quality T2-weighted MR imaging in MS at 7 T, improving (cortical) lesion detection. Key Points • Magnetization prepared 3D-FLAIR and 3D-DIR 7 T MRI provide high quality isotropic images. • MS lesions are well demonstrated by 3D-MP-FLAIR and 3D-MP-DIR at 7 T MRI. • 3D-MP-FLAIR and 3D-MP-DIR at 7 T MRI show many more Virchov-Robin spaces.Keywords
This publication has 30 references indexed in Scilit:
- High‐Resolution Phased‐Array MRI of the Human Brain at 7 Tesla: Initial Experience in Multiple Sclerosis PatientsJournal of Neuroimaging, 2010
- Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 TeslaEuropean Radiology, 2010
- Double Inversion Recovery MRI with Fat Suppression at 7 Tesla: Initial ExperienceJournal of Neuroimaging, 2009
- Fluid attenuated inversion recovery (FLAIR) MRI at 7.0 Tesla: comparison with 1.5 and 3.0 TeslaEuropean Radiology, 2009
- In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRINeurology, 2009
- A Comparison of 3T and 7T in the Detection of Small Parenchymal Veins Within MS LesionsInvestigative Radiology, 2009
- Examination of the role of magnetic resonance imaging in multiple sclerosis: A problem-orientated approachAnnals of Indian Academy of Neurology, 2009
- Multiplicity of cerebrospinal fluid functions: New challenges in health and diseaseFluids and Barriers of the CNS, 2008
- Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathologyNeurochemistry International, 2004
- Multislice T1 relaxation time measurements in the brain using IR‐EPI: Reproducibility, normal values, and histogram analysis in patients with multiple sclerosisJournal of Magnetic Resonance Imaging, 2003