Antimalarial Activity of Macrocyclic Trichothecenes Isolated from the Fungus Myrothecium verrucaria
- 1 December 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (2), 329-331
- https://doi.org/10.1021/np980323x
Abstract
Bioassay-guided fractionation of an extract from the fungus Myrothecium verrucaria BCC 112 resulted in the first isolation of roridin E acetate (5) from nature together with four common macrocyclic trichothecene isomers (1−4). Trichothecenes 1−5, while known as mycotoxins, were evaluated for their high antimalarial activity.Keywords
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