Biomechanics of early cardiac development
- 4 July 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Biomechanics and Modeling in Mechanobiology
- Vol. 11 (8), 1187-1204
- https://doi.org/10.1007/s10237-012-0414-7
Abstract
Biomechanics affect early cardiac development, from looping to the development of chambers and valves. Hemodynamic forces are essential for proper cardiac development, and their disruption leads to congenital heart defects. A wealth of information already exists on early cardiac adaptations to hemodynamic loading, and new technologies, including high-resolution imaging modalities and computational modeling, are enabling a more thorough understanding of relationships between hemodynamics and cardiac development. Imaging and modeling approaches, used in combination with biological data on cell behavior and adaptation, are paving the road for new discoveries on links between biomechanics and biology and their effect on cardiac development and fetal programming.Keywords
This publication has 159 references indexed in Scilit:
- A Guide to Analysis of Cardiac Phenotypes in the Zebrafish EmbryoMethods in cell biology, 2011
- Quantifying blood flow and wall shear stresses in the outflow tract of chick embryonic heartsComputers & Structures, 2011
- Hemodynamic patterning of the avian atrioventricular valveDevelopmental Dynamics, 2010
- Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6Developmental Biology, 2009
- Patterns of muscular strain in the embryonic heart wallDevelopmental Dynamics, 2009
- Concepts of Cardiac Development in RetrospectPediatric Cardiology, 2009
- The development of the heart and microcirculation: role of shear stressMedical & Biological Engineering & Computing, 2008
- Signals from both sides: Control of cardiac development by the endocardium and epicardiumSeminars in Cell & Developmental Biology, 2006
- Xenopus as a model system for vertebrate heart developmentSeminars in Cell & Developmental Biology, 2006
- A series of normal stages in the development of the chick embryoDevelopmental Dynamics, 1992