Antibacterial effect of fucoidan from Sargassum wightii against the chosen human bacterial pathogens

Abstract

The present study was aimed to evaluate the antibacterial capability of fucoidan from Sargassum wightii against the chosen human bacterial pathogens. The major chemical constituents of the extracted fucoidan were analyzed by biochemical methods. It showed that the extracted fucoidan contains 52.86 ± 0.64% of fucose and 29.26 ± 0.83% of sulphate. The antibacterial efficacy was performed by agar well diffusion, minimum inhibitory concentration (MIC) and minimum inhibitory concentration (MBC) method. The maximum antibacterial activity 18.6 ± 0.32 mm was obtained for Vibrio cholera and the minimum activity 8.6 ± 0.26 mm was obtained for Salmonella typhi. Result of this manifested the considerable antibacterial potentiality of fucoidan against human bacterial pathogens. Toxicity of fucoidan was evaluated by brine shrimp toxicity assay. No toxic effect was observed in fucoidan. Our study concluded that fucoidan might be used as natural and safe antibiotics in curing many bacterial diseases. Further study is required to get the better understanding of mode of action of fucoidan against the bacterial pathogens.DOI: http://dx.doi.org/10.3329/icpj.v2i10.16408 International Current Pharmaceutical Journal, September 2013, 2(10): 156-158