Identification of a recent recombination event within the human beta-globin gene cluster.
- 1 December 1984
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 81 (24), 7875-7879
- https://doi.org/10.1073/pnas.81.24.7875
Abstract
In a detailed study of inheritance of DNA sequence polymorphism in a large reference pedigree, an individual was identified with an apparent genetic recombination event within the human .beta.-globin gene cluster. Analysis of the haplotypes of relevant individuals within this pedigree suggested that the meiotic crossing-over event is likely to have occurred within a 19.8-kilobase-pair region of the .beta.-globin gene cluster. Analysis of other DNA markers closely linked to the .beta.-globin gene cluster.sbd.segment 12 of chromosome 11 (D11S12) and loci for insulin, the cellular oncogene c-Ha-ras, and preproparathyroid hormone.sbd.confirmed that a crossover event must have occurred within the region of chromosome 11 between DS11S12 and the .beta.-globin gene cluster. The event has apparently occurred within a DNA region compatible with recombinational hot spots suggested by population studies.This publication has 25 references indexed in Scilit:
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